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Seminar - ID 266 - Academic year 2009-2010
2D Myocardial Strain Estimation in the Mouse using Speckle Tracking.
 

Oct 08, 2009 - 12h00

  
 

aud. Louvre

  
  Florence Kremer  
 

 
  Myocardial strain quantification in the mouse based on 2D speckle tracking using real time ultrasound data sets is feasible but remains challenging. The major difficulty lies in the fact that the frame rate to heart rate ratio is relatively low, causing significant de-correlation between successive frames.Furthermore, estimating strain in the lateral direction is also difficult due to the lack of phase information. This appears to be even more the case in the murine setting given that the kernel width has to be small in order to obtain multiple motion estimation across the wall as required for strain estimation.

In this setting, regularization is therefore particularly important in order to discard motion estimates that are unlikely. Multiple regularization methods have been proposed in the literature among which a class of regularizers based on enforcing preset geometrical characteristics of the motion field. To date, these regularization methods have not been contrasted.

In this seminar, we will first give a short overview of what is currently used in small animal imaging. Then, we will present how less overlap between kernels can improve lateral motion estimation in conditions of small kernel to speckle size ratio. After that, we will compare the performance of different geometric regularizers in the setting of myocardial strain in murine echocardiography using simulated data sets.